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Viagra is promising as a treatment for dogs with often fatal eating disorders

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Sildenafil, a generic version of a drug known as Viagra, could become a long-awaited remedy for a group of dogs with a rare disease called megastrovond.


The condition includes increased esophagus and loss of the body’s ability to move food into the stomach, which leaves bottled food at the bottom of the esophagus. If left untreated, many animals vomit food and aspirate food into their lungs, causing aspiration pneumonia.

“Literature tells us that many dogs with the disease die from aspiration pneumonia or subjected to humane euthanasia because of poor quality of life for eight months after diagnosis, ”said Dr. Gillian Haynes, a veterinarian at Washington State University who led the study.

Liquid sildenafil it has been shown to relax the smooth muscles of the lower esophagus so that it opens to allow food to pass into the stomach. Apart from the rare gastrointestinal irritation, at the dose used in the study, there were no side effects for the dogs. While sildenafil is best known for treatment erectile dysfunctionThe drug is also used to treat high pulmonary blood pressure in dogs and humans.

A study conducted at the WSU College of Veterinary Medicine was published in American Journal of Veterinary Research.

“If you look at the literature, there are no drugs we can use to fight mega-breeders. Sildenafil first controls these mechanisms and reduces regurgitation, which is very large because that’s what ultimately kills these dogs,” Haynes said. “It opens the lower esophageal sphincter 20 minutes to an hour, which works very well for dogs because we want it to open only while eating.”

Veterinarians WSU Dr. Susan Mehain and Sarah Gues along with Haynes conducted the study. Three researchers used video fluorography to monitor liquid and then mixed wet food as it traveled through the esophagus.

Ten megaesophageal dogs in the study were given placebo or sildenafil for two weeks. The dogs then went drug-free for one week. The placebo and sildenafil groups were then changed.

Their owners were instructed to record episodes of belching, but were not informed of which drug their dog was taking.

There was no significant difference between placebo and sildenafil during the 30-minute video fluorography when veterinarians used moving X-rays to investigate how food was swallowed. However, the study found that nine out of 10 owners reported decreased regurgitation within two weeks when using liquid sildenafil.

“In many cases, owners were able to find out which drug was sildenafil because it worked,” Haynes said.

By the end of the study, the considered dogs were also gaining an average of just over 2 pounds.

“Dogs with moderately affected, who often vomited but not excessively, seemed to see the most dramatic results,” Haynes said. “I actually prescribed sildenafil to several of these patients after the study, and they still use it today.”

Dogs in which severe signs of the disease were found did not show such positive results. In these cases, the researchers found that getting the drug into the stomach for absorption was harder.

Although the study is promising, Haynes said much remains to be known about the drug. She hopes future research will investigate the use of sildenafil in veterinary medicine.

“A lot of vets turn up and ask about it drug“Haynes said.” I think sildenafil will change and save the lives of many dogs. This study helps support its use and hopefully encourage more people to use it. ”

Haynes said it is important to note the efforts of the owners in these studies.

“It’s always important to recognize the commitment of owners in these studies because without their success in veterinary medicine it’s just impossible, ”she said.


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Additional information:
Susan O. Mehain et al., Randomized cross-sectional study of joint liquid sildenafil for the treatment of generalized megastoresum in dogs, American Journal of Veterinary Research (2022). DOI: 10.2460 / ajvr.21.02.0030

Citation: Viagra promising for the treatment of dogs with often fatal eating disorders (2022, February 21) obtained February 21, 2022 from https://phys.org/news/2022-02-viagra-treatment-dogs-fatal-disorder .html

This document is subject to copyright. Except for any honest transaction for the purpose of private study or research, no part may be reproduced without written permission. The content is provided for informational purposes only.



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Viagra is promising as a treatment for dogs with often fatal eating disorders

Credit: CC0 Public Domain

Sildenafil, a generic version of a drug known as Viagra, could become a long-awaited remedy for a group of dogs with a rare disease called megastrovond.


The condition includes increased esophagus and loss of the body’s ability to move food into the stomach, which leaves bottled food at the bottom of the esophagus. If left untreated, many animals vomit food and aspirate food into their lungs, causing aspiration pneumonia.

“Literature tells us that many dogs with the disease die from aspiration pneumonia or subjected to humane euthanasia because of poor quality of life for eight months after diagnosis, ”said Dr. Gillian Haynes, a veterinarian at Washington State University who led the study.

Liquid sildenafil it has been shown to relax the smooth muscles of the lower esophagus so that it opens to allow food to pass into the stomach. Apart from the rare gastrointestinal irritation, at the dose used in the study, there were no side effects for the dogs. While sildenafil is best known for treatment erectile dysfunctionThe drug is also used to treat high pulmonary blood pressure in dogs and humans.

A study conducted at the WSU College of Veterinary Medicine was published in American Journal of Veterinary Research.

“If you look at the literature, there are no drugs we can use to fight mega-breeders. Sildenafil first controls these mechanisms and reduces regurgitation, which is very large because that’s what ultimately kills these dogs,” Haynes said. “It opens the lower esophageal sphincter 20 minutes to an hour, which works very well for dogs because we want it to open only while eating.”

Veterinarians WSU Dr. Susan Mehain and Sarah Gues along with Haynes conducted the study. Three researchers used video fluorography to monitor liquid and then mixed wet food as it traveled through the esophagus.

Ten megaesophageal dogs in the study were given placebo or sildenafil for two weeks. The dogs then went drug-free for one week. The placebo and sildenafil groups were then changed.

Their owners were instructed to record episodes of belching, but were not informed of which drug their dog was taking.

There was no significant difference between placebo and sildenafil during the 30-minute video fluorography when veterinarians used moving X-rays to investigate how food was swallowed. However, the study found that nine out of 10 owners reported decreased regurgitation within two weeks when using liquid sildenafil.

“In many cases, owners were able to find out which drug was sildenafil because it worked,” Haynes said.

By the end of the study, the considered dogs were also gaining an average of just over 2 pounds.

“Dogs with moderately affected, who often vomited but not excessively, seemed to see the most dramatic results,” Haynes said. “I actually prescribed sildenafil to several of these patients after the study, and they still use it today.”

Dogs in which severe signs of the disease were found did not show such positive results. In these cases, the researchers found that getting the drug into the stomach for absorption was harder.

Although the study is promising, Haynes said much remains to be known about the drug. She hopes future research will investigate the use of sildenafil in veterinary medicine.

“A lot of vets turn up and ask about it drug“Haynes said.” I think sildenafil will change and save the lives of many dogs. This study helps support its use and hopefully encourage more people to use it. ”

Haynes said it is important to note the efforts of the owners in these studies.

“It’s always important to recognize the commitment of owners in these studies because without their success in veterinary medicine it’s just impossible, ”she said.


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Additional information:
Susan O. Mehain et al., Randomized cross-sectional study of joint liquid sildenafil for the treatment of generalized megastoresum in dogs, American Journal of Veterinary Research (2022). DOI: 10.2460 / ajvr.21.02.0030

Citation: Viagra promising for the treatment of dogs with often fatal eating disorders (2022, February 21) obtained February 21, 2022 from https://phys.org/news/2022-02-viagra-treatment-dogs-fatal-disorder .html

This document is subject to copyright. Except for any honest transaction for the purpose of private study or research, no part may be reproduced without written permission. The content is provided for informational purposes only.



Reported by Source link

RELATED ARTICLES
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